More and more often, practitioners in the process industry have to adapt their global production networks to changes in the competitive environment. A majority of the supply network design models proposed by academia do not sufficiently capture the economic and technical questions that need to be resolved. This work seeks to provide the necessary operations research decision support tools. It builds on the example of the specialty chemicals industry, which faces a strong increase in competitive pressure and historically grown production networks that typically lack a coherent design strategy. Decision makers have to define a global production network re-design strategy. Therefore, the book proposes a planning process split into two phases: global production network optimization and individual site selection. To support the former, a comprehensive mixed-integer linear programming model is proposed.