In the late seventies, Albert Hofmann expressed his deep disappointment with the fate of the "wonder drug" he had discovered: "LSD - my troubled child" was the title of the memoir published at that time. While the substance had been celebrated in the sixties as a royal road to exploring the psyche, a backlash soon followed: hallucinogens were banned across the board, a consequence of the "War on Drugs." Today, the taboo seems to be crumbling: worldwide discussions are taking place about the legalization of marijuana; young people are flocking to the Amazon to embark on journeys to the beyond with Ayahuasca; medical professionals are exploring the therapeutic potential of MDMA and the psychedelic drug psilocybin; even mainstream cinema is shaking the gates of perception. The authors shed light on the renaissance of the psychedelic from various perspectives and speak with neuroscientists and users.