"Target Discovery and Validation Reviews and Protocols" is a comprehensive collection of expertise that addresses the latest methods for the discovery and validation of drug targets. The two volumes provide deep insights into the advancements achieved through an improved understanding of the molecular mechanisms of human diseases and their impact on drug development, particularly in cancer and autoimmune diseases. Volume 1 focuses on innovative techniques and current protocols aimed at maximizing targeted inhibition in vivo while minimizing side effects. The influence of genomics, proteomics, and bioinformatics on target discovery is thoroughly discussed, with an emphasis on the role of transgenic and knockout animals in functional genomics. Volume 2, on the other hand, offers practical details for the efficient implementation of discovered targets into pharmaceutical products and highlights specific targets in oncology and autoimmunity. These volumes are essential resources for researchers and clinicians working at the intersection of basic research and clinical application.