Their first case, their worst killer. New York City has been thrown into chaos by the assaults of the Bone Collector, a serial kidnapper and killer who gives the police a chance to save his victims from death by leaving obscure clues. Baffled, the cops turn to the one man with a chance of solving them - Lincoln Rhyme. Left paralyzed by a debilitating accident, ex-NYPD cop Rhyme has to dig deep into the only world he has left - his astonishing mind - to have any hope of solving the case. With the help of a young police officer, Amelia Sachs, he starts to close in on the killer. But as he edges closer to the truth, the Bone Collector is closing in on Lincoln Rhyme himself.