In 1965, a young research scientist named Margot Sharpe meets Elihu Hoopes, the subject of her study, a handsome amnesiac who cannot remember anything beyond the last seventy seconds. Over the course of thirty years, the two embark on mirroring journeys of self-discovery. Margot, enthralled by her charming, mysterious, and deeply lonely patient, as well as her officious supervisor, attempts to unlock Eli's shuttered memories of a childhood trauma without losing her own sense of identity in the process. And Eli, haunted by memories of an unknown girl's body underneath the surface of a lake, pushes to finally know himself once again, despite potentially devastating consequences. As Margot and Eli meet over and over again, Joyce Carol Oates' tightly written, almost clinical prose propels the lives of these two characters forward, both suspended in a dream-like shadow.