Acne vulgaris is a common human skin disorder characterized by seborrhea, comedones, papules, pustules, nodules, and possibly scarring. Clindamycin, a lincosamide antibiotic, is most commonly used for the treatment of acne compared to other available treatments because it directly kills the bacteria associated with acne. However, Clindamycin hydrochloride has a major drawback of very low topical bioavailability of only 4-5%. Therefore, a hypothesis was made that Clindamycin, when entrapped in liposomes, could improve topical bioavailability. This research project focused on the formulation and evaluation of Clindamycin hydrochloride liposomes. This book covers all aspects and parameters considered for the research project along with their results. From the research work, it can be concluded that topical liposomes may be a promising future direction.