Shortly after Robert Koch established solid pathways in bacteriology, the conviction emerged that it is not so much the bacteria themselves that cause the devastating effects of infectious diseases; it was soon recognized that these tiny organisms are mostly only indirectly harmful; it must be their chemical products that represent the actual toxin. Particularly, Brieger was one of the first to point out that one must search for the specific toxins of bacteria, and he himself was eager to seek out and identify these supposed toxins. All bacteria produce various chemical substances in the media that host them. Although many of the bacterial substances presented in various ways are products of secondary transformations due to overly intrusive chemical manipulations, certainly a part of them is.