The book "Treatment of Acute Leukemias: New Directions for Clinical Research" offers a comprehensive analysis of current approaches to the treatment of acute leukemias. It highlights advancements in therapy and the ongoing challenges associated with improving event-free survival rates and reducing the toxic side effects of curative treatments. International experts discuss the best diagnostic and therapeutic practices for newly diagnosed and relapsed acute lymphoblastic and myeloid leukemia in children, adolescents, and adults. The discussion covers a variety of therapies, including methotrexate, asparaginase, and immunotherapy, as well as key topics such as central nervous system therapy and the issue of minimal residual disease. The balanced perspective provided by various research groups ensures a thorough view of the current challenges and future research directions in oncology.