Global developments and events in the environment are increasingly triggering existential reactions in the human organism. What can we do about it? How can we reduce our stress levels? This is an important question, especially for professionals in therapeutic, psychosocial, and educational fields. There are situations in life where one loses orientation and people become unbalanced. Stress is inevitable. But how exactly do stress reactions occur in the body, and what distinguishes existential stress from everyday experiences? Based on fundamental scientific findings, Georg Endres and Gerhard Bergmann present understandable and practical approaches for a new way of dealing with stress. They demonstrate how small steps in the professional and private spheres can lead to a new orientation and a healthier life. The proposed systemic interventions offer an immediate transfer into practice and support a realignment. Professionals in the psychosocial field are provided with practical alternatives and protective measures to prevent their own states of exhaustion. The approaches offer guidance for expanded action orientation and management, as only when those providing support are well-positioned themselves can they help others in stressful situations.