The history of pain relief, the immersion into consciousness and painlessness under the guise of deep sleep, dates back to Homeric times. The "Nepenthes" of the ancient Greeks, the use of mandrake by Greeks and Romans, the Moa-Tho (cannabis) by Chinese doctors, and the inhalation of narcotic substances (Datura, cannabis) to induce a state of unconsciousness and ecstasy, as practiced by the Scythians, Hindus, and Northern Greeks (Oracle at Delphi), and which is still said to be used by some Native American tribes, all belong to this context. The production of local anesthesia and analgesia through plant-based remedies, which is of particular interest to us here, has also been practiced since ancient times. Let us set aside the more discussed applications of mandrake, hyoscyamus, aconite, opium, and Indian substances.