The aim of this manual is to compile the new knowledge and experiences in the various areas of mechanical solid-liquid separation for the design of equipment and processes, and to present it in a way that facilitates its application. This cross-industry manual is aimed at engineers and technicians in practice, as well as students, and covers topics such as sampling and test evaluation, particle size distributions and evaluation of separations, labeling of solid-liquid mixtures, flocculation, sedimentation practices, flotation devices, filtration equipment, processes and systems of membrane filtration, pressing devices, centrifuges, hydrocyclones, equipment usage, and technical-economic orientation, as well as selected examples of typical separation tasks.