From a procedure for specialists in research, the LC/MS coupling has developed into a proven routine application. The aim of this book is to provide LC/MS users with as much detailed information as possible, enabling them to carry out their LC/MS applications optimally. After an overview of the current state of technology and instrumental requirements, aspects of method development are discussed. A chapter with tips and tricks leads to user reports, which also include a look beyond classical HPLC to ion chromatography. Reports from renowned equipment manufacturers on the latest developments round off the book. This practical guide provides LC/MS users with the information they need for the optimal use of their equipment: from instrumental requirements and method development to user and manufacturer reports.