The consumption of cocaine and synthetic drugs, which have both euphoric and performance-enhancing effects, is on the rise. The risks are often underestimated, even within the medical community. Synthetic drugs are offered in an ever-growing variety of forms and combinations, some of which are legal. The handbook provides a precise overview of current manufacturing forms, chemical compositions, physical and psychological mechanisms of action, as well as symptoms and short- and long-term consequences. Doctors receive detailed recommendations for diagnostics and therapy, both in emergencies and in chronic treatment. Based on years of personal experience, the author outlines typical deception attempts by patients and potential errors by doctors. The handbook should be available as a readily accessible reference in every emergency room, intensive care unit, addiction clinic, and addiction practice.